A great deal of anecdotal evidence was available "on the street" that methadone might prove effective in treating heroin withdrawal and is not uncommonly used in hospitals and other de-addiction centers to enhance rates of completed opioid withdrawal.
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A lot of research is still done on this chemical. Farbenkonzern at the Farbwerke Hoechst were confiscated by the U. Methadone was introduced into the United States in by Eli Lilly and Company as an analgesic under the trade name Dolophine,  which is now registered to Roxane Laboratories.
In fact, injection of methadone does not result in a " rush " as with some other strong opioids such as morphine or hydromorphonebecause its extraordinarily high volume of distribution causes it to diffuse into other tissues in the body, particularly fatty tissue; the peak concentration in the blood is achieved at roughly the same time, whether the drug is injected or ingested.
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Metabolism[ edit ] Methadone has a slow metabolism and very high fat solubilitymaking it longer lasting than morphine-based drugs.
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